Figure 7.

Comparison of HSP90-Dependent Proteins in Resting and Activated Primary T Cells

(A) Scatterplots comparing global effects of HSP90 inhibition on mature proteins in resting (left) and anti-CD3/CD28 activated (right) primary T cells. Protein fold changes of 17-AAG versus vehicle treated samples are shown for two donors (full graph in Figure S7A). Significantly regulated proteins are marked in red (p < 0.05); the dashed line is the equality line.

(B) Line chart with markers of fold changes for mature forms of selected proteins in resting (blue) and activated T cells (red) upon treatment with 17-AAG relative to vehicle control.

(C) Line chart with markers of fold changes determined for nascent heat shock family members in resting (blue) and activated T cells (red) upon treatment with 17-AAG relative to vehicle control.

Triangles and circles indicate the two donors. Significance is indicated by an asterisk (p < 0.05) (B and C).

See also Table S3.