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. 2018 Mar 28;8:5349. doi: 10.1038/s41598-018-23703-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Summary of significant and nominally significant findings in Notch pathway mRNA expression between the bipolar disorder and the healthy control group after controlling for age, gender and Bmal1. Results are given as p-values, adjusted for multiple testing, where significant results are indicated in red/dark blue (for increased/decreased mRNA expression) and nominally significant results (0.001 < p < 0.05) are shown as pink/light blue (for increased/decreased mRNA expression). Non-significant results are depicted as boxes with white background. The figure is based on the Notch signaling pathway in the KEGG database (hsa04330, version date 5/9/17). Hey1 is included by the authors due to its known role as a target gene for Notch signaling³⁰.