Table 2.
Differences between groups for plasma markers of Notch pathway after controlling for age and gender.
| plasma ligands | M(IQR) | SCZ vs. HC | BD vs. HC | SCZ vs. BD | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SCZ | BD | HC | df | t | F | df | t | F | df | t | F | |
| DLL1 | 5 (1.8) | 4.7 (1.6) | 4.5 (1.3) | 1232 | 8.8*** | 32.01*** | 889 | 3.26** | 10.81*** | 848 | 3.00** | 9.13*** |
| DLK1 | 186 (170) | 188 (164) | 180 (149) | 1243 | 2.23* | 10.62*** | 893 | 2.00* | 11.38*** | 854 | 0.08 | 9.06*** |
*p < 0.05 **p < 0.03 ***p < 0.001
Abbreviations: M = median; IQR = interquartile range; SCZ = schizophrenia; BD = bipolar disorder; HC = healthy controls; DLL1 = Delta-like protein 1; DLK1 = Delta Like Non-Canonical Notch Ligand 1.
ANCOVA using linear regression models. Results are significant if p < 0.03, and nominally significant if 0.03 < p < 0.05 (Bonferroni correction).