Table 3.
Significant differences between patients and controls in Notch signaling pathway gene mRNA expression after controlling for age and gender.
| Genes | specificity | SCZ vs. HC | BD vs. HC | SCZ vs. BD | |
|---|---|---|---|---|---|
| B | B | B | |||
| Receptor and Cytoplasm | LFNG | +++ | −0.01 | 0.07** | −0.09*** |
| RFNG | +++ | 0.11*** | 0.07*** | 0.03 | |
| NOTCH2 | +++ | 0.01 | −0.04** | 0.06*** | |
| DTX3L | +++ | 0.05*** | 0.00 | 0.05** | |
| PSEN1 | ++ | −0.03*** | −0.02*** | −0.01 | |
| Nucleus | KAT2B | ++ | 0.16*** | 0.13*** | 0.03 |
| CREBBP | + | −0.10*** | −0.09*** | −0.01 | |
| CTBP1 | ++ | −0.03*** | −0.01 | −0.02* | |
| CTBP2 | ++ | −0.03*** | −0.01 | −0.02** | |
| HDAC1 | ++ | −0.08*** | −0.04* | −0.04* | |
| HDAC2 | ++ | −0.06*** | −0.05* | −0.01 | |
| RBPJ | + | −0.07*** | −0.01 | −0.06** |
*p < 0.05 **p < 0.01 ***p < 0.001
Specificity: + (unspecific, involved in many pathways), ++ (involved in up to 3 additional pathways e.g. Wnt, NF-kappa), +++ (exclusively Notch pathway related gene).
Abbreviations: SCZ = Schizophrenia; BD = Bipolar disorder; HC = Healthy controls; B = Unstandardized regression coefficient.
Gene names are listed according to the HUGO Gene Nomenclature Committee.
Results are given as effect size estimates from the linear regression analysis after correction for age, sex and BMAL1 expression. Results are significant if p < 0.001, and nominally significant if 0.001 < p < 0.05 (Bonferroni correction).