Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 25;1:24. doi: 10.1038/s41698-017-0028-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Sinusoidal microfluidic device used in the study and summary of clinical results. a Schematic of the dual selection strategy using mAbs directed against FAPα and EpCAM cell-surface antigens. b SEM of the CTC selection microfluidic device. c Optical micrographs of the CTC selection microchip filled with whole blood, and the chip after rinsing with buffer. d An image (5×) of DAPI-stained Hs578T cells isolated within the channels of the microfluidic device. e Simulation of CTC recovery from blood at different translational velocities as a function of cell rolling distance along the mAb decorated surface. f Box plots for CTCs isolated from the blood of healthy donors, patients with non-cancerous disease, CRPC, M- PDAC, M-CRC, M-BC, and M-EOC. CTC counts were normalized to 1 ml of blood. g Test positivity in cancer patients’ blood using the single EpCAM approach and the dual selection strategy (test positivity based on the CTC^FAPα and/or CTC^EpCAM counts exceeding a level that was 3× SD for counts from non-cancer patients)