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. 2018 Mar 21;9:258. doi: 10.3389/fphys.2018.00258

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Copyright © 2018 Sorriento, De Luca, Trimarco and Iaccarino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Angiotensin II-dependent ROS production induces hypertension. Angiotensin II induces ROS production through the activation of mitochondrial enzymes and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox). Angiotensin II-dependent ROS production causes in turn a significant reduction of eNOS activity and NO production, lipid peroxidation, induction of apoptotic signaling, and NFκB activation. These all lead to endothelial dysfunction and vascular inflammation that trigger the development of the hypertensive state.