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. 2018 Mar 28;8:5341. doi: 10.1038/s41598-018-23424-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MSCT analysis. (A) The Apollo software (Vida Diagnostics, Iowa, USA) was used to segment the lobes from the MSCT scans. The resulting contour of the right lung lobes is presented here using custom software written in Matlab (R2015b, MathWorks, Natick, MA 01760–2098, US). (B) Illustration of the extracted branch center lines, along with the segmented airway tree for one of the participants. The center lines are colored according to generation number. Note that for the purposes of illustration, the center lines are plotted between the branch points only. For all of the analysis described in this paper, the complete center line information was used, which captured the true shape of the airways as in Fig. 8.