Table 3.
SVR12 in cirrhotic and non-cirrhotic hepatitis C virus genotype 1b-infected patients with and without resistance-associated polymorphisms at baseline (immediate treatment arm) n (%)
Patients with cirrhosis - immediate treatment arm |
||||||||
With RAPs at baseline |
Without RAPs at baseline |
|||||||
Mainland China | Russia | South Korea | Overall | Mainland China | Russia | South Korea | Overall | |
Patients with cirrhosis | ||||||||
NS5A-L31M/V | 0 | 0 | 0 | 0 | 15/16 (93.8) | 0 | 2/3 (66.7) | 17/19 (89.5) |
Y93H | 0 | 0 | 0 | 0 | 15/16 (93.8) | 0 | 2/3 (66.7) | 17/19 (89.5) |
L31M/V or Y93H | 0 | 0 | 0 | 0 | 15/16 (93.8) | 0 | 2/3 (66.7) | 17/19 (89.5) |
NS3-D168E | 0 | 0 | 0 | 0 | 15/16 (93.8) | 0 | 2/3 (66.7) | 17/19 (89.5) |
Patients without cirrhosis | ||||||||
NS5A-L31M/V | 1/1 (100) | 1/1 (100) | 0 | 2/2 (100) | 93/101 (92.1) | 21/22 (95.5) | 8/10 (80.0) | 122/133 (91.7) |
Y93H | 7/13 (53.8) | 0 | 0/2 (0) | 7/15 (46.7) | 87/89 (97.8) | 22/23 (95.7) | 8/8 (100) | 117/120 (97.5) |
L31M/V or Y93H | 8/14 (57.1) | 1/1 (100) | 0/2 (0) | 9/17 (52.9) | 86/88 (97.7) | 21/22 (95.5) | 8/8 (100) | 115/118 (97.5) |
NS3-D168E | 0/1 (0) | 0 | 0 | 0/1 (0) | 94/101 (93.1) | 22/23 (95.7) | 8/10 (80.0) | 124/134 (92.5) |
RAP: Resistance-associated polymorphism; SVR12: Sustained virologic response at posttreatment week 12.