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. 2018 Mar 28;24(12):1361–1372. doi: 10.3748/wjg.v24.i12.1361

Table 5.

SVR12 in cirrhotic and noncirrhotic hepatitis C virus genotype-1b-infected patients with and without resistance-associated polymorphisms at baseline (placebo-deferred treatment arm) n (%)

Patients with cirrhosis - placebo-deferred treatment arm
With RAPs at baseline
Without RAPs at baseline
Mainland China Russia South Korea Overall Mainland China Russia South Korea Overall
Patients with cirrhosis
NS5A-L31M/V 0 0 0 0 3/5 (60.0) 1/1 (100) 1/1 (100) 5/7 (71.4)
Y93H 1/3 (33.3) 0 0 1/3 (33.3) 2/2 (100) 1/1 (100) 1/1 (100) 4/4 (100)
L31M/V or Y93H 1/3 (33.3) 0 0 1/3 (33.3) 2/2 (100) 1/1 (100) 1/1 (100) 4/4 (100)
NS3-D168E 0 0 0 0 3/5 (60.0) 1/1 (100) 1/1 (100) 5/7 (71.4)
Patients without cirrhosis
NS5A-L31M/V 0 0 0 0 30/36 (83.3) 5/5 (100) 2/2 (100) 37/43 (86.0)
Y93H 1/5 (20.0) 0 0 1/5 (20.0) 29/31 (93.5) 5/5 (100) 2/2 (100) 36/38 (94.7)
L31M/V or Y93H 1/5 (20.0) 0 0 1/5 (20.0) 29/31 (93.5) 5/5 (100) 2/2 (100) 36/38 (94.7)
NS3-D168E 0 0 0 0 30/36 (83.3) 5/5 (100) 2/2 (100) 37/43 (86.0)

RAP: Resistance-associated polymorphism; SVR12: Sustained virologic response at posttreatment week 12.