Table 5.
SVR12 in cirrhotic and noncirrhotic hepatitis C virus genotype-1b-infected patients with and without resistance-associated polymorphisms at baseline (placebo-deferred treatment arm) n (%)
Patients with cirrhosis - placebo-deferred treatment arm |
||||||||
With RAPs at baseline |
Without RAPs at baseline |
|||||||
Mainland China | Russia | South Korea | Overall | Mainland China | Russia | South Korea | Overall | |
Patients with cirrhosis | ||||||||
NS5A-L31M/V | 0 | 0 | 0 | 0 | 3/5 (60.0) | 1/1 (100) | 1/1 (100) | 5/7 (71.4) |
Y93H | 1/3 (33.3) | 0 | 0 | 1/3 (33.3) | 2/2 (100) | 1/1 (100) | 1/1 (100) | 4/4 (100) |
L31M/V or Y93H | 1/3 (33.3) | 0 | 0 | 1/3 (33.3) | 2/2 (100) | 1/1 (100) | 1/1 (100) | 4/4 (100) |
NS3-D168E | 0 | 0 | 0 | 0 | 3/5 (60.0) | 1/1 (100) | 1/1 (100) | 5/7 (71.4) |
Patients without cirrhosis | ||||||||
NS5A-L31M/V | 0 | 0 | 0 | 0 | 30/36 (83.3) | 5/5 (100) | 2/2 (100) | 37/43 (86.0) |
Y93H | 1/5 (20.0) | 0 | 0 | 1/5 (20.0) | 29/31 (93.5) | 5/5 (100) | 2/2 (100) | 36/38 (94.7) |
L31M/V or Y93H | 1/5 (20.0) | 0 | 0 | 1/5 (20.0) | 29/31 (93.5) | 5/5 (100) | 2/2 (100) | 36/38 (94.7) |
NS3-D168E | 0 | 0 | 0 | 0 | 30/36 (83.3) | 5/5 (100) | 2/2 (100) | 37/43 (86.0) |
RAP: Resistance-associated polymorphism; SVR12: Sustained virologic response at posttreatment week 12.