Table 3.

Subtype stratified univariate analyses for all patients.

	Follicle Density	Germinal Center Density	Non-circular Follicles	Non-circular Germinal Centers	Mantle Zone Ratio	Mφ	TILs
Luminal-A vs. all other subtypes	p =  < 0.001 cc = −0.293	p = 0.001 cc = −0.197	p = 0.252 cc = 0.066	p < 0.436 cc = −0.048	p = 0.106 cc = −0.093	p = 0.003 cc = 0.168	p = 0.043 cc = −0.041
Luminal-B vs. all other subtypes	p =  < 0.001 cc = −0.232	p = 0.028 cc = −0.125	p < 0.765 cc = −0.017	p = 0.565 cc = −0.035	p = 0.608 cc = −0.029	p =  < 0.001 cc = 0.316	p = 0.022 cc −0.160
Luminal-Her2 vs. all other subtypes	p =  < 0.001 cc = 0.202	p = 0.397 cc = 0.049	p = 0.334 cc = 0.055	p = 0.446 cc = −0.047	p = 0.768 cc = 0.017	p = 0.015 cc = −0.139	p = 0.672 cc = −0.030
Her2-enriched vs. all other subtypes	p = 0.763 cc = 0.017	p = 0.106 cc = 0.093	p = 0.233 cc = −0.068	p = 0.158 cc = −0.087	p = 0.104 cc = 0.093	p = 0.003 cc = −0.168	p = 0.262 cc = 0.078
Triple-negative vs. all other subtypes	p =  < 0.001 cc = 0.407	p =  < 0.001 cc = 0.253	p = 0.145 cc = −0.084	p = 0.273 cc = 0.067	p = 0.271 cc = 0.063	p =  < 0.001 cc = −0.336	p < 0.001 cc = 0.286

Spearman Rho correlation coefficient (cc) calculation was performed for all items (p value is provided over the cc value). Follicle density and germinal center density were calculated by number of follicles or germinal centers over lymph node area; calculation of non-circular follicles and germinal centers is described in the methods part; mantle zone ratio was calculated as area ratio of each germinal center over the corresponding follicle; Mφ: cortical macrophage infiltrations as defined in the methods part; TIL: tumor infiltrating lymphocytes as defined in the methods part.