Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Targeted therapies in melanoma
| Target gene | Alteration | Drug type | Candidate |
|---|---|---|---|
| BRAF | Amplification/mutation | BRAF inhibitor | Vemurafenib, dabrafenib |
| MEK | Amplification/mutation | MEK inhibitor | Trametinib, cobimetinib |
| CTLA-4 | Amplification | CTLA-4 inhibitor | Ipilimumab |
| PD-1 | − | PD-1 inhibitor | Nivolumab, pembrolizumab |
