Fig. 7.

Cellular consequences of centriole length deregulation. In cancer cells, over elongated centrioles induce centriole amplification through centriole fragmentation and/or ectopic procentriole formation along the elongated centrioles. Elongated centrioles also generate larger MTOCs with a higher capacity to nucleate MTs that enhance chromosome instability during mitosis. Both scenarios could give rise to aneuploidy and might as well induce invasiveness, therefore centriole length deregulation might participate to tumour initiation and progression