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. Author manuscript; available in PMC: 2018 Mar 28.
Published in final edited form as: J Med Chem. 2017 Aug 18;60(17):7244–7255. doi: 10.1021/acs.jmedchem.7b00228

Figure 5.

Figure 5

Compound 38u prevents breast-to-lung metastasis in vivo. (A) Representative mouse lungs of animals treated with vehicle control or 3 or 10 mg/kg compound 38u. Bottom panel depicts IHC staining. (B) Quantification of metastasized cancer nodules found on the treated and untreated mouse lungs demonstrates that significantly less nodules are present in the lungs of the drug-treated mice. (C) The proportion of mice exhibiting metastatic nodules in lungs decreased as the drug treatment dosage increased.