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. Author manuscript; available in PMC: 2018 Mar 28.
Published in final edited form as: J Med Chem. 2017 Aug 18;60(17):7244–7255. doi: 10.1021/acs.jmedchem.7b00228

Table 1.

Caco-2 Permeability

Compound A ->B Papp (10-6 cm•s-1) B ->A Papp (10-6 cm•s-1) RE
Ranitidine 0.2 1.3 8.1
Warfarin 35.5 8.6 0.2
Talinolol 0.3 5.4 16.8
38 1.1 20.3 18.2
38D-16 0.9 3.0 3.3
38D-21 2.7 7.0 2.6
38D-22 10.0 30.5 3.0

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