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. 2018 Mar 28;8:5301. doi: 10.1038/s41598-018-23591-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Blind event rating. Three raters independently labeled one same event they observed in one of the 106 capillaries of the study. (a–c) Capillary-video frames (indexed top right) with cross-shaped event marks from rater 1 (blue), 2 (green) and 3 (yellow). (d) Aggregated positions of all event marks from all three raters. (e) ST map displaying the recorded brightness levels along the segmented capillary length (vertical axis) as a function of time (horizontal axis) for a 1.7-second interval around the event of interest. A bright trajectory created by the passage of the event is clearly identified in the center of the ST map. Blue, green, and yellow crosses correspond to the ST coordinates where each rater labeled the event.