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Two eCBs act at CB1 and CB2 receptors with differing affinities and efficacies. AEA, N-arachidonylethanolamine; CB1R, subtype 1 of the cannabinoid receptor; CB2R, subtype 2 of the cannabinoid receptor; 2-AG, 2-arachidonoylglycerol. Affinity refers to the ability of the eCB and receptor to form a bound complex and efficacy refers to the ability of the eCB to induce signaling via the receptor.
