Fig. 2.

Structural models for wild-type (WT) hLADH and its five pathogenic mutants (structures #1) in their low-pH forms in water plus ions. Only monomer A is shown with different colors for domains: FAD-binding domain (1–149) – purple, NAD⁺/NADH-binding domain (150–282) – green, central domain (283–350) – orange, and interface domain (351–474) – blue. Structures were created and rendered in Pymol. Representative fittings of I318T- or G101del-hLADH (low-pH) to WT-hLADH (low-pH) can be seen in Fig. S2A,B. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)