Fig. 4.

A representative plot of ratios of specific, functionally significant, interatomic distances for the R447G mutant structure (#2) relative to the respective low-pH WT-hLADH structure in water plus ions. The serial numbers on the abscissa axis refer to the numbering scheme of distances in Fig. S3. Ratios greater than 2 are filtered out from plots and collected in Table 2 under the “structure mapping” columns.