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. 2018 Jan 9;8(1):6. doi: 10.3390/bios8010006

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Nanoplasmonic inhibition assay for D3R-antagonist antipsychotic drug. (A) Sensorgrams obtained for indirect detection of buspirone at different concentrations (5 nM–5 mM). (B) Standard dose-response inhibition curve for indirect detection of Buspirone. Plots represent mean and standard deviation of each buspirone concentration (1 nM–5 mM) measured in triplicate. (C) Sensorgrams obtained for negative control drugs (i.e., etoposide and APAP), compared to pure D3R-AuNPs detection. (D) Signal comparison between dopamine, antipsychotic drugs, and control drugs at the same concentration (6.5 μM). Statistical analysis (n = 5) confirmed that differences between control drugs signals and free D3R are not significant (p < 0.05).