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. 2018 Jan 30;8(1):8. doi: 10.3390/jpm8010008

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Conventional and Genetic Regulators of Response. Conventional clinical (and cellular) factors and also genetic other factors regulate response to clopidogrel. ABCB1: ATP-Binding Cassette Subfamily B Member 1; ADP: adenosine diphosphate; CES: Carboxylesterase 1; CYP: cytochrome P450, particularly CYP2C19; GPIIB/IIIa: Glycoprotein IIB/IIIa; PON1: Serum paraoxonase/arylesterase 1; P2Y: receptor on the surface of platelets. Used with permission of Creative Commons; copyright 2017 [11]; originally adapted from [128].