Table 5.
Distribution of gene polymorphisms per control and cancer groups across racial groups.
| n (%) | Control Group | Cancer Group | ||||||
|---|---|---|---|---|---|---|---|---|
| Genotypes | 0 | 1 | 2 | p-value (HWE) | Population Allele Frequency | 0 | 1 | 2 |
| MTHFR 677 | CC | CT | TT | % C/T | CC | CT | TT | |
| Total | 28 (51.9) | 21 (44.4) | 5 (9.3) | NS | 75/25 | 23 (42.6) | 25 (46.3) | 6 (11.1) |
| White | 8 (50.0) | 7 (43.8) | 1 (6.2) | NS | 53/47 | 5 (27.8) | 9 (50) | 4 (22.2) |
| Asian | 12 (52.2) | 8 (34.8) | 3 (13.0) | NS | 70/30 | 9 (47.4) | 9 (47.4) | 1 (5.2) |
| Hispanic | 4 (36.4) | 6 (54.5) | 1 (9.1) | NS | 55/45 | 4 (33.3) | 7 (58.3) | 1 (8.3) |
| Black | 4 (100) | 0 (0) | 0 (0) | - | 91/9 | 5 (100) | 0 (0) | 0 (0) |
| MTHFR 1298 | AA | AC | CC | % A/C | AA | AC | CC | |
| Total | 32 (59.2) | 15 (27.8) | 7 (13) | 0.0314 | 75/25 | 34 (63) | 15 (27.8) | 5 (9.3) |
| White | 7 (43.8) | 6 (37.5) | 3 (18.8) | NS | 85/15 | 11 (61.1) | 6 (33.3) | 1 (5.6) |
| Asian | 16 (69.6) | 5 (21,7) | 2 (8.7) | NS | 78/22 | 13 (68.4) | 4 (21.1) | 2 (10.5) |
| Hispanic | 5 (45.4) | 4 (36.4) | 2 (18.2) | NS | 84/16 | 5 (41.7) | 5 (41.7) | 2 (16.7) |
| Black | 4 (100) | 0 (0) | 0 (0) | - | 85/15 | 5 (100) | 0 (0) | 0 (0) |
| MTR 2756 | AA | AG | GG | % A/G | AA | AG | GG | |
| Total | 39 (72.2) | 12 (22.2) | 3 (5.6) | NS | 36 (66.7) | 17 (31.5) | 1 (1.8) | |
| White | 10 (62.5) | 4 (25.0) | 2 (12.5) | NS | 84/16 | 10 (55.5) | 7 (38.9) | 1 (5.5) |
| Asian | 17 (73.9) | 5 (21.7) | 1 (4.3) | NS | 65–91/9–35 | 13 (68.4) | 6 (31.6) | 0 (0) |
| Hispanic | 11 (100) | 0 (0) | 0 (0) | - | 19/81 | 10 (83.3) | 2 (16.7) | 0 (0) |
| Black | 1 (25) | 3 (75) | 0 (0) | NS | 30–37/63–70 | 3 (60.0) | 2 (40.0) | 0 (0) |
| MTRR 66 | AA | AG | GG | % A/G | AA | AG | GG | |
| Total | 28 (52.6) | 18 (33.4) | 7 (13) | NS | 64/36 | 19 (35.6) | 25 (46.8) | 10 (18.5) |
| White | 3 (18.8) | 6 (37.5) | 7 (43.8) | NS | 45/55 | 4 (22.2) | 9 (50.0) | 5 (27.8) |
| Asian | 14 (63.6) | 8 (36.4) | 0 (0) | NS | 74/26 | 6 (31.6) | 10 (52.6) | 3 (15.8) |
| Hispanic | 10 (90.9) | 1 (9.1) | 0 (0) | NS | 72/28 | 7 (58.3) | 3 (25.0) | 2 (16.7) |
| Black | 1 (25.0) | 3 (75.0) | 0 (0) | NS | 73/27 | 2 (40.0) | 3 (60.0) | 0 (0) |
| DHFR 19 bp | II | ID | DD | % I/D | II | ID | DD | |
| Total | 20 (37) | 17 (31.5) | 17 (31.5) | 0.0068 | 50/50 | 13 (24.1) | 25 (46.3) | 16 (29.6) |
| White | 2 (12.5) | 6 (37.5) | 8 (50.0) | NS | 45–47/53–55 | 1 (5.6) | 11 (61.1) | 6 (33.3) |
| Asian | 15 (65.2) | 6 (26.1) | 2 (8.7) | NS | 63/37 | 9 (47.4) | 7 (36.8) | 3 (15.8) |
| Hispanic | 2 (18.2) | 4 (36.4) | 5 (45.4) | NS | 58/42 | 2 (16.7) | 3 (25.0) | 7 (58.3) |
| Black | 1 (25.0) | 1 (25.0) | 2 (50.0) | NS | 55/45 | 1 (20.0) | 4 (80.0) | 0 (0) |
HWE: Hardy–Weinberg equilibrium; - not available; NS: Not significant; HWE calculator: http://www.koonec.com/k-blog/2010/06/20/hardy-weinberg-equilibrium-calculator/; http://useast.ensembl.org/index.html; https://www.cdc.gov/genomics/population/genvar/frequencies/mthfr.htm.