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Islet viability: None of the SPIOs showed negative effects on the viability of islet cells (FDA/propidium iodide staining) after labeling. (B) In order to generate magnetic resonance (MR)-detectable uptake by using Resovist, without addition of PLL, 72 h of incubation was necessary. But severe effects on the islet viability were observed after such prolonged incubation times. (C) Non-labeled islets immediately after isolation. Scale bar: (A,B) 100 μm, (C) 200 μm.
