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45S5 Bioglass® reaction stages related to time increase.
| Stage | Reaction Event |
|---|---|
| 11 | Crystallization of matrix |
| 10 | Cellular attachment |
| 9 | Differentiation of steam cells |
| 8 | Attachment of steam cells |
| 7 | Action of macrophages |
| 6 | Adsorption of biological moieties |
| 5 | Nucleation and crystallization of calcium phosphate to HCA |
| 4 | Precipitation of amorphous calcium phosphate |
| 3–2 | Dissolution and re-polymerization of surface silica |
| 1 | Ion exchange |
| 0 | Initial glass surface |
