Figure 6.

A total of nine core (i.e., conserved in ≥80% of genomes) SMGCs were found in both NDR and SDR. The NDR clade had 11 core SMGCs and the SDR clade had 15 core SMGCs. The tree reflects phylogenetic relationships between Streptomyces sister-taxa genomes and was constructed from multiple whole genome alignments (see Figure 1). Scale bar represents nucleotide substitutions per site. Tree branches are colored according to clade affiliation. Core orthologous SMGCs (depicted by colored circles) were determined using the antiSMASH [32] MIBiG annotation pipeline or were defined using our annotation-independent approach (see Materials and Method). Colors correspond to SMGC class (see legend), and natural product annotations are labeled if available.