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. 2018 Mar 18;7(1):25. doi: 10.3390/antibiotics7010025

Figure 5.

Figure 5

Model for the effects of NDPs on the activity S. coelicolor PNPase. The model posits that S. coelicolor PNPase (PacMan symbol) is able to phosphorolyze 5650 and other structured substrates to a limited extent in the absence of NDPs, as indicated by the dashed X. In the presence of NDPs, PNPase synthesizes unstructured 3′-tails in vivo, and these tails then provide an anchor for the enzyme, thus facilitating the digestion of structured substrates. Copyright © American Society for Microbiology (J. Bacteriol. 195, 2013, 5151–5159, DOI:10.1128/JB.00936-13) [49].