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. Author manuscript; available in PMC: 2018 Mar 28.
Published in final edited form as: ACS Chem Neurosci. 2017 Jan 6;8(4):712–717. doi: 10.1021/acschemneuro.6b00334

Figure 4.

Figure 4

Inhibition of homomeric α7 nAChR by ethylatropine bromide. (A) Whole-cell currents were recorded from an oocyte 4 days after injection with cRNAs encoding α7. After application of EAB (300 μM), the peak current of the homomeric α7 receptor elicited by acetylcholine (1 mM) was reduced. The inhibition was reversed upon removal of EAB. (B) Varying the concentration of EAB revealed significant inhibition only at 30 μM and 300 μM, but not at 3 μM. **p < 0.01; one-way ANOVA with Dunnett’s posthoc tests. The number within the bar represents the total number of oocytes within each group. Data are mean ± SEM.