Table 2.
Significant changes in ΔcadA proteome compared to TIGR4.
| Description | Protein | ΔcadA/TIGR4 (Fold Change) | Function |
|---|---|---|---|
| N-carbamoylputrescine amidase | *SP_0922 | −10.0 | Putrescine biosynthesis |
| Carboxynorspermidine decarboxylase | NspC | −5.0 | Spermidine biosynthesis |
| Homoserine dehydrogenase | Hom | −1.4 | Lysine biosynthesis |
| 4-hydroxy-tetrahydrodipicolinate synthase | DapA | −10.0 | Lysine biosynthesis |
| 4-hydroxy-tetrahydrodipicolinate reductase | DapB | −2.5 | Lysine biosynthesis |
| N-acetyldiaminopimelate deacetylase | SP_2096 | −2.5 | Lysine biosynthesis |
| Saccharopine dehydrogenase | Lys9 | −25.0 | Lysine biosynthesis |
| Aspartate-semialdehyde dehydrogenase | Asd | −25.0 | Lysine biosynthesis |
| 2,3,4,5-tetrahydropyridine-2-carboxylate N-Succinyl transferase | DapH | −1.7 | Lysine biosynthesis |
| 50S ribosomal protein L21 | RplU | −5.0 | Regulation of protein elongation |
| Ribosome maturation factor | RimP | -5.0 | Regulation of protein maturation |
| Lysine-tRNA ligase | LysS | −3.3 | Amino acid metabolism |
| Iron-compound ABC Transporter | FhuD | −50.0 | Iron complex ABC transporter |
| Phosphate-binding protein PstS 2 | PstS 2 | 41.0 | Phosphate ion transport |
| Phosphate import ATP-binding protein PstB 3 | PstB 3 | 36.0 | Phosphate ion transport |
| Phosphate transport system permease protein | PstC | 7.0 | Phosphate ion transport |
| Phosphate-specific transport system accessory protein PhoU homolog | PhoU | 43.0 | Phosphate ion transport |
| ABC transporter, ATP-binding/permease protein | SP_2073 | −3.3 | Oligopeptide ABC transporter |
| Oligopeptide binding protein | OppA | −25.0 | Oligopeptide ABC transporter |
| Oligopeptide transport ATP-binding protein | OppD | −1.4 | Oligopeptide ABC transporter |
| Oligopeptide transport ATP-binding protein | OppF | −1.7 | Oligopeptide ABC transporter |
| Oligopeptide transport system permease protein | OppB | −1.7 | Oligopeptide ABC transporter |
| Manganese ABC transporter-substrate-binding lipoprotein | PsaA | 2.4 | Oxidative stress |
| Manganese ABC transporter, ATP -binding protein | PsaB | 6.8 | Oxidative stress |
| Penicillin-binding protein 2x | Pbp2X | −2.5 | Peptidoglycan biosynthesis |
| Choline kinase | Pck | −2.0 | Cell wall biosynthesis |
| UDP-glucose 4-epimerase | GalE-1 | −1.3 | Carbohydrate metabolism |
| Tagatose 1,6-diphosphate aldolase | LacD | 1.4 | Carbohydrate metabolism |
| Galactose-6-phosphate isomerase subunit | LacB | 2.1 | Carbohydrate metabolism |
| Catabolite control protein A | CcpA | −2.5 | Carbohydrate metabolism |
| Bifunctional protein | GlmU | −1.7 | UDP- GlcNAc synthesis |
| N-acetylglucosamine-6-phosphate deacetylase | NagA | 1.4 | N-acetylglucosamine degradation |
| N-acetylglucosamine-6-phosphate deaminase | NagB | 2.1 | N-acetylglucosamine degradation |
| Transketolase, C-terminal subunit | TktC | 67.0 | Pentose phosphate pathway |
| Transketolase, N-terminal subunit | TktN | 46.0 | Pentose phosphate pathway |
| Ascorbate-specific PTS, EIIC component | SgaT2 | 31.0 | Ascorbate utilization |
| Ascorbate-specific PTS system, EIIB component | SgaB2 | 32.0 | Ascorbate utilization |
| Phosphocarrier protein HPr | PtsH | 21.0 | Phosphotransferase system (PTS) |
*: locus tag ID; ABC: ATP binding cassette; ATP: Adenosine triphosphate; UDP: uridine diphosphate; GlcNac: N-acetylglucosamine; PTS: phosphotransferase system.