Table 2.
Clinical trials of silver diamine fluoride (SDF) to arrest caries in young children in China.
| Author, Year [Reference] | Duration, Children | Intervention Group | Caries Arrest Rate | Risk of Bias */Quality ** |
|---|---|---|---|---|
| Wang et al. 1984 [46] | 18 months, 68 children, 3.5–4.5 years |
Gp 1: 38% SDF every 3 to 4 months Gp 2: Control |
Gp 1: 85% Gp 2: 31% (p < 0.001) |
Moderate/Poor |
| Ye et al. 1995 [47] | 12 months, 300 primary teeth |
38% SDF, one off | 92% | High/Poor |
| Chu et al. 2002 [42] | 30 months, 375 children, 3–5 years |
Gp 1: Caries removal + 38% SDF once yearly Gp 2: 38% SDF once yearly Gp 3: Caries removal + 5% NaF 4 times yearly Gp 4: 5%NaF 4 times yearly Gp 5: Water (Control) |
Gp 1: 60% Gp 2: 66% Gp 3: 37% Gp 4: 40% Gp 5: 34% (p < 0.001) |
Moderate/Fair |
| Yang et al. 2002 [48] | 6 months, 50 children, 3–6 years |
38% SDF, one off | 94% | High/Poor |
| Zhi et al. 2012 [45] | 24 months, 212 children, 3–4 years |
Gp 1: 38% SDF once yearly Gp 2: 38% SDF 2 times yearly |
Gp 1: 79%, Gp 2: 91% (p < 0.05) |
Low/Good |
| Duangthip et al. 2016 [44] | 18 months, 304 children, 3–4 years |
Gp 1: 30% SDF once yearly Gp 2: 30% SDF 3 times weekly at baseline Gp 3: 5% NaF 3 times weekly at baseline |
Gp 1: 40% Gp 2: 35% Gp 3: 27% (p < 0.001) |
Low/Good |
| Fung et al. 2017 [43] | 30 months, 888 children, 3–4 years |
Gp 1: 12% SDF once yearly Gp 2: 12% SDF 2 times yearly Gp 3: 38% SDF once yearly Gp 4: 38% SDF 2 times yearly |
Gp 1: 55% Gp 2: 59% Gp 3: 67% Gp 4: 76% (p < 0.001) |
Low/Good |