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Membrane activity of potent HDP mimetics. (a) Propidium iodide (PI) incorporation in Candida albicans exposed to HDP mimetics. PI incorporation after 0–30 min treatments with 32 µg/mL of each HDP mimetic. 95% ethanol was used as a positive control, in which 100% PI entered the cell within 7 min. No PI was taken up in untreated yeast cells. (b) Calcium chloride inhibition of MIC of potent HDP mimetics. MIC assays were carried out in the presence of increasing concentrations of CaCl2.
