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. 2018 Feb 27;4(1):30. doi: 10.3390/jof4010030

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Comparison of HDP mimetic efficacy at 50% MTD. Mean log₁₀ reduction of colony forming units (cfu) of Candida albicans following SC treatment with different HDP mimetics at 50% of the maximum tolerated dose (MTD) 2 h following IV infection with 3.5 × 10⁴ cfu/mouse for 24 h. For comparison, female Swiss CD.1 mice were gavaged 2 h after infection with 20 mg/kg fluconazole for 24 h, which caused a 3-log reduction in cfu. Groups were compared to a control group dosed with kleptose and infected with 3 × 10⁴ cfu C. albicans per mouse.