Table 1.

MIC study of eleven HDP mimetics.

Compound	1	2	3	4	5	6	7	8	9	10	11	Fluconazole	Caspofungin
Series	Tri-aryl	Bis-amide	Tri-cyclic	Tri-cyclic	Bis-amide	Bis-amide	Bi-aryl	Bis-amide	Bis-amide	Bi-aryl	Bi-aryl
Activity against C. albicans (μg/mL)
MIC	4	4	2	4	4	4	4	8	>8	0.3	8	0.25	0.25
MFC	8	16	8	8	8	8	8	16	>8	0.78	ND		0.5
MIC+50% Human serum	4	4	16	4	16	16	16	32	>8	ND	>8
NAC species MIC (μg/mL)
C. tropicalis	4–8	8	4	2–4	2	4	8	4	2	ND	1
C. parapsilosis	4–8	1	1	2	1	2	2	4	0.5	ND	0.25
C. dublinensis	8	32	16	4	2	2	4	4	ND	ND	ND
C. glabrata	4	8	2	2	4	4	4	8	>8	ND	1
C. krusei	32	8	0.50	16	2	2	4	4	1	ND	4

ND, not determined.