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. 2018 Mar 21;9:88. doi: 10.3389/fpsyt.2018.00088

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Copyright © 2018 Liao, Johnson, Qi, Wu, Xie, Liu, Yang, Huang, Zhang, Liu, Hao and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased brain regions of activation by different cues. Increased brain regions of activation in chronic ketamine users during exposure to ketamine use-related films when compared with control subjects [smokers and non-smokers (A)]; increased brain regions of activation in chronic smokers (chronic ketamine users were also chronic smokers) during exposure to smoking-related films when compared with non-smokers (B); increased brain regions of activation in control subjects (smokers and non-smokers) during exposure to sexual films when compared with chronic ketamine users (C); in respects to ketamime cue minus smoking cue, increased brain regions of activation in chronic ketamine users when compared with chronic smokers (D). AlphaSim corrected p < 0.005.