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. 2018 Mar 27;37:72. doi: 10.1186/s13046-018-0741-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Palbociclib up-regulates the PI3K/AKT/mTOR pathway in TNBC cells. MDA-MB-231 and HCC38 cells were treated with increasing concentrations of palbociclib for 24 h (a) or with a fixed drug concentration for different periods of time (b). Then, the expression of the indicated proteins was analyzed by Western blotting. Results are representative of three independent experiments