Table 3.
Weight change (as % of initial body weight; mean, 95% confidence interval) per genotype at 3 and 12 months of treatment in individuals that completed 12 months of treatment (n = 275)
| Gene | rs number | Genotype | Weight change at 3 months | Genotype difference | p value1 | Weight change at 12 months | Genotype difference | p value1 |
|---|---|---|---|---|---|---|---|---|
| PLIN1 | rs2289487 | C/C (n = 39) | −5.3 (−5.9, −4.7) | −0.2 (−1.2, 0.8) | 0.722 | −9.3 (−112, −7.5) | −1.9 (−3.9, 0.1) | 0.059 |
| T/T-T/C (n = 234) | −5.1 (−6.0, −4.2) | −7.4 (−8.2, −6.7) | ||||||
| PLIN1 | rs2304795 | G/G (n = 38) | −4.8 (−6.0, −3.7) | 0.5 (−0.8, 1.8) | 0.473 | −6.7 (−8.8, −5.1) | 0.9 (−11, 2.9) | 0.378 |
| A/A-G/A (n = 230) | −5.3 (−5.9, −4.8) | −7.9 (−8.1, −6.6) | ||||||
| PLIN1 | rs1052700 | T/T (n = 42) | −6.4 (−8.0, −4.8) | −1.3 (−2.7, 0.1) | 0.058 | −9.1 (−10.9, −7.4) | −1.7 (−3.7, 0.2) | 0.077 |
| A/A-T/A (n = 232) | −5.1 (−5.6, −4.6) | −7.4 (−8.1, −6.6) | ||||||
| MMP2 | rs1132896 | C/C (n = 43) | −5.6 (−6.6, −4.5) | −0.4 (−1.7, 0.9) | 0.552 | −8.2 (−9.9, −6.4) | −0.6 (−2.5, 1.3) | 0.578 |
| C/G-G/G (n = 227) | −5.2 (−5.7, −4.7) | −7.6 (−8.3, −6.8) | ||||||
| PPARγ | rs1801282 | C/C (n = 211) | −3.9 (−6.4, −1.5) | 1.3 (−2.2, 4.8) | 0.454 | −7.2 (−8.0, −6.4) | 1.9 (0.2, 3.5) | 0.027 |
| C/G-G/G (n = 63) | −5.3 (−5.8, −4.8) | −9.1 (−10.5, −7.6) | ||||||
| TIMP4 | rs3755724 | T/C (n = 122) | −5.0 (−5.8, −4.3) | 0.4 (−0.6, 1.4) | 0.422 | −8.2 (−9.2, −7.1) | −0.9 (−2.3, 0.5) | 0.191 |
| C/C-T/T (n = 148) | −5.4 (−6.0, −4.8) | −7.2 (−8.2, −6.3) |
1
p value from a mixed model ANOVA analysis comparing weight loss at 3- and 12-month follow-up among genotypes (not corrected for multiple SNPs).