Table 4.
Pharmacokinetic parameters of curdione and curcumol in rat blood and liver after administration of R-CR and V-CR (n = 5).
| Parameters | Blood | Liver | Blood-to-liver distribution | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| T max (h) | C max (μg/L) | AUC0~T (μg/L•h) | AUC0~∞ (μg/L•h) | MRT0~T (h) | T max (h) | C max (μg/L) | AUC0~T (μg/L•h) | AUC0~∞ (μg/L•h) | MRT0~T (h) | AUCliver/AUCblood | |
| R-CR | |||||||||||
| Curdione | 3.50 ± 1.12 | 107.79 ± 18.86 | 240.76 ± 49.53 | 269.71 ± 36.18 | 4.76 ± 0.65 | 4.00 ± 2.29 | 17.10 ± 5.13 | 87.61 ± 16.67 | 130.03 ± 18.53 | 7.24 ± 1.85 | 0.37 ± 0.08 |
| Curcumol | 2.00 ± 0.00 | 164.63 ± 26.23 | 312.17 ± 62.79 | 416.18 ± 96.25 | 3.89 ± 0.42 | 2.90 ± 0.22 | 111.67 ± 24.07 | 262.68 ± 53.00 | 400.91 ± 181.67 | 5.65 ± 3.80 | 0.85 ± 0.11 |
| V-CR | |||||||||||
| Curdione | 3.00 ± 0.00 | 84.70 ± 18.55 | 199.86 ± 68.10 | 245.29 ± 79.99 | 5.28 ± 0.82 | 2.40 ± 0.22 | 22.53 ± 9.63 | 108.65 ± 43.75 | 145.98 ± 52.62 | 6.12 ± 0.64 | 0.55 ± 0.09∗ |
| Curcumol | 2.00 ± 0.00 | 135.14 ± 41.08 | 277.10 ± 103.13 | 369.83 ± 113.77 | 4.00 ± 1.10 | 3.30 ± 0.27 | 94.59 ± 36.89 | 240.53 ± 101.58 | 308.60 ± 117.57 | 3.92 ± 0.11 | 0.86 ± 0.09 |
∗ P < 0.05, unpaired t-test (two-sided) when value of V-CR group was compared to that of R-CR.