Table 6.
Top 10 upregulated and downregulated mRNAs in COPD patients compared with smokers.
| Gene symbol | Gene name | Fold change Smokers versus nonsmokers (P value) |
Fold change COPD versus nonsmokers (P value) |
Fold change COPD versus smokers (P value) |
Function |
|---|---|---|---|---|---|
| Upregulation | |||||
| CD177 | CD177 molecule | 3.48 (0.0056) | 78.70 (0.0029) | 22.59 (0.0030) | Leukocyte migration |
| MUC17 | Mucin 17,cell surface associated | 1.08 (0.2270) | 23.22 (0.0030) | 21.54 (0.0030) | Extracellular matrix constituent |
| IL1R2 | Interleukin 1 receptor, type II | 0.92 (0.7332) | 10.08 (0.0033) | 10.96 (0.0033) | Decoy receptor, inhibits the activity of IL-1 |
| SARDH | Sarcosine dehydrogenase | 0.19 (0.0045) | 1.83 (0.0100) | 9.52 (0.0033) | Mitochondrial matrix |
| EGR3 | Early growth response 3 | 1.12 (0.1549) | 7.57 (0.0035) | 6.75 (0.0036) | Positive regulation of endothelial cell proliferation |
| AREG | Amphiregulin | 0.65 (0.0319) | 4.01 (0.0071) | 6.16 (0.0048) | EGF family, promote the growth of normal epithelial cells |
| SLC6A2 | Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 | 0.39 (0.0093) | 1.84 (0.0099) | 4.70 (0.0042) | Sodium symporter |
| TMEM167A | Transmembrane protein 167A | 0.79 (0.8343) | 3.68 (0.0435) | 4.55 (0.0077) | Golgi apparatus |
| KCNJ15 | Potassium inwardly-rectifying channel, subfamily J, member 15 | 0.78 (0.5713) | 3.45 (0.0049) | 4.42 (0.0043) | Potassium channel activity |
| FCHO1 | FCH domain only 1 | 0.26 (0.0057) | 1.15 (0.0381) | 4.39 (0.0043) | Clathrin-mediated endocytosis |
| Downregulation | |||||
| IL1A | Interleukin 1, alpha | 2.03 (0.0117) | 0.05 (0.0031) | 0.02 (0.0029) | Immune response |
| IL6 | Interleukin 6 (interferon, beta 2) | 1.59 (0.0111) | 0.10 (0.0044) | 0.06 (0.0032) | Proinflammatory and anti-inflammatory role |
| CXCL10 | Chemokine (C-X-C motif) ligand 10 | 1.06 (0.2735) | 0.07 (0.0033) | 0.07 (0.0033) | Leukocyte chemotaxis |
| TNF | Tumor necrosis factor | 0.43 (0.0112) | 0.04 (0.0030) | 0.085 (0.0035) | Inflammation, cause apoptosis |
| CCL20 | Chemokine (C-C motif) ligand 20 | 1.06 (0.2724) | 0.13 (0.0041) | 0.13 (0.0039) | Lymphocytes chemotaxis |
| CCL4 | Chemokine (C-C motif) ligand 4 | 0.87 (0.3686) | 0.14 (0.0045) | 0.16 (0.0047) | Leukocyte chemotaxis |
| CCL3L3 | Chemokine (C-C motif) ligand 3-like 3 | 0.89 (0.5755) | 0.17 (0.0066) | 0.19 (0.0063) | Leukocyte chemotaxis |
| C9orf7 | Chromosome 9 open reading frame 7 | 1.40 (0.0126) | 0.27 (0.0070) | 0.19 (0.0049) | Calcium channel activity |
| IL1RN | Interleukin 1 receptor antagonist | 0.90 (0.5833) | 0.19 (0.0051) | 0.21 (0.0053) | Inhibition of the activities of IL-1 |
| RNF19B | Ring finger protein 19B | 2.21 (0.0099) | 0.53 (0.0362) | 0.24 (0.0059) | Cytotoxic effects of natural killer (NK) cells |
Table reproduced from Dang et al. [10], under the Creative Commons Attribution License/public domain.