Table 3.
Relative expressions of adipogenic and lipogenic genes of mice liver tissue after 8-week treatment with fermented Cucurbita moschata extract.
| Gene | ND | HFD | HFD + 0.3% HCA | HFD + 0.1% FCME | HFD + 0.3% FCME | HFD + 0.5% FCME |
|---|---|---|---|---|---|---|
| PPAR-γ | 1.00 ± 0.00bc | 1.62 ± 0.14a | 1.21 ± 0.09abc | 0.83 ± 0.07c | 0.76 ± 0.05c | 1.38 ± 0.09ab |
| SREBP-1C | 1.00 ± 0.00b | 1.77 ± 0.02a | 1.18 ± 0.03b | 1.08 ± 0.10b | 1.07 ± 0.09b | 1.04 ± 0.13b |
| CEBP-α | 1.00 ± 0.00b | 1.58 ± 0.04a | 1.03 ± 0.11b | 1.40 ± 0.14ab | 1.32 ± 0.08ab | 1.37 ± 0.15ab |
| CEBP-β | 1.00 ± 0.00c | 1.76 ± 0.06a | 1.39 ± 0.05b | 1.03 ± 0.13c | 1.29 ± 0.06bc | 1.30 ± 0.03bc |
| CEBP-γ | 1.00 ± 0.00a | 1.27 ± 0.04a | 1.22 ± 0.03a | 0.61 ± 0.05b | 1.00 ± 0.10a | 0.99 ± 0.05a |
| ACC1 | 1.00 ± 0.00 | 1.06 ± 0.06 | 0.88 ± 0.02 | 0.93 ± 0.01 | 1.09 ± 0.03 | 1.01 ± 0.04 |
| FAS | 1.00 ± 0.00 | 1.18 ± 0.06 | 1.22 ± 0.08 | 1.34 ± 0.12 | 1.47 ± 0.09 | 1.32 ± 0.19 |
| GLUT4 | 1.00 ± 0.00c | 0.39 ± 0.01d | 1.07 ± 0.03bc | 1.46 ± 0.08ab | 0.94 ± 0.04c | 1.53 ± 0.09a |
| LPL | 1.00 ± 0.00 | 1.10 ± 0.08 | 0.94 ± 0.09 | 0.92 ± 0.02 | 0.84 ± 0.06 | 0.87 ± 0.08 |
ND: normal diet; HFD: high fat diet; HCA: hydroxycitric acid; FCME: fermented Cucurbita moschata extract. PPAR-γ: peroxisome proliferator-activated receptor-γ; C/EBP-α: CCAAT/enhancer binding protein-α; C/EBP-β: CCAAT/enhancer binding protein-β; C/EBP-γ: CCAAT/enhancer binding protein-γ; FAS: fatty acid synthase; LPL: lipoprotein lipase; GLUT4: glucose transporter 4; SREBP-1C: sterol regulatory element-binding protein-1C; ACC1: acetyl-CoA carboxylase 1; values not having the same superscript letter are significantly different (p < 0.05) by ANOVA.