Figure 2.

Survival is reduced in response to intermittent hypoxia in a murine model of lung fibrosis. Kaplan-Meier plot of mice survival after bleomycin exposure in normoxia and intermittent hypoxia (IH). Eight-week-old mice received an intratracheal instillation of bleomycin or saline (NaCl) at day 0. Survival of mice (n = 23–41) after bleomycin was significantly decreased compared with controls (n = 14–16). Exposure to IH worsened mice survival. p < 0.0001 by Log-rank test. ^∗p < 0.05 versus Saline-IA; ^∗∗p < 0.01 versus Saline-IA.