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. 2018 Mar 13;2018:2627917. doi: 10.1155/2018/2627917

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Copyright © 2018 Nenad Stojiljkovic et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Light photomicrographs of PAS-stained sections of rat renal cortex showing normal histology of kidney tissue and regular morphology of microvilli-covered epithelial surface, with thin and well-defined basement membranes in control (c) group (a) nanoliposomes (NL) group (b), lycopene (LYC) group (c), and encapsulated nanoliposomes (ENL) group (d); significant destruction of brush border (marked with arrow), and presence of PAS-positive tubular casts (marked with asterisk) in (e) methotrexate (MTX) and (f) methotrexate-empty nanoliposomes (MTX-NL) group; attenuation of visible changes, with less destruction of brush in rats treated with methotrexate and lycopene (MTX-LYC group) (g) and almost complete prevention of histopathological alterations in group treated with methotrexate and encapsulated nanoliposomes (MTX-ENL group) (h). (PAS, original magnification, 400x).