Table 2.
Comparison of PNPLA3 rs738409, TM6SF2 rs58542926, KLF6 rs3750861, SOD2 rs4880, and LPIN1 rs13412852 polymorphisms prevalence, according to study subgroups.
| Healthy Subjects | Noncirrhotic NAFLD | NASH cirrhosis | p | |
|---|---|---|---|---|
| PNPLA3 | ||||
| CC | 53 (58.9%) | 30 (32.3%)++ | 20 (18.7%)++ | <0.001 |
| CG | 30 (33.3%) | 36 (38.7%)++ | 44 (41.1%)++ | |
| GG | 7 (7.8%) | 27 (29%)++ | 43 (40.2%)++ | |
| TM6SF2 | ||||
| CC | 79 (87.8%) | 74 (79.6%) | 79 (73.8%) | 0.105 |
| CT | 11 (12.2%) | 17 (18.3%) | 27 (25.2%) | |
| TT | 0 (0%) | 2 (2.2%) | 1 (0.9%) | |
| TM6SF2 dichotomized | ||||
| CC | 79 (87.8%) | 74 (79.6%) | 79 (73.8%)+ | 0.06 |
| CT/TT | 11 (12.2%) | 19 (20.4%) | 28 (26.2%)+ | |
| KLF6 | ||||
| CC | 79 (87.8%) | 80 (86%) | 83 (77.6%) | 0.224 |
| CT | 11 (12.2%) | 13 (14%) | 23 (21.5%) | |
| TT | 0 (0%) | 0 (0%) | 1 (0.9%) | |
| KLF6 dichotomized | ||||
| CC | 79 (87.8%) | 80 (86%) | 83 (77.6%) | 0.113 |
| CT/TT | 11 (12.2%) | 13 (14%) | 24 (22.4%) | |
| SOD2 | ||||
| CC | 26 (28.9%) | 20 (21.5%) | 30 (28%) | 0.795 |
| CT | 42 (46.7%) | 48 (51.6%) | 49 (45.8%) | |
| TT | 22 (24.4%) | 25 (26.9%) | 28 (26.2%) | |
| LPIN1 | ||||
| CC | 38 (42.2%) | 45 (48.4%) | 49 (45.8%) | 0.672 |
| CT | 41 (45.6%) | 37 (39.8%) | 50 (46.7%) | |
| TT | 11 (12.2%) | 11 (11.8%) | 8 (7.5%) |
Data are shown as absolute number and column percentages. p for overall chi-square test. +p < 0.05 and ++p < 0.001 versus healthy subjects; PNPLA3: patatin-like phospholipase domain containing protein 3; TM6SF2: transmembrane 6 superfamily member 2; KLF6: Kruppel-like factor 6; SOD2: superoxide dismutase 2; LPIN1: lipin 1.