Table 3.
Top ten SNPs identified by the generalized linear model (GLM; sorted by p-value). The SNPs identified from “ΔC × SNP” in model (1), from “ΔF × SNP” in model (1), from “ΔTC × SNP” in model (2), and from “SNP” in model (3) were used to determine polygenic effectiveness for changes in carbohydrate intake (CE), fat intake (FE), total calorie intake (TE), and exercise status (EE), respectively. For polymorphisms in linkage disequilibrium (LD), only SNPs with the smallest p-values were selected to represent each group; this procedure was performed for each category. The coefficient estimates and p-values were obtained from a single SNP analysis using GLM.
| Category | SNP | Estimate | p-Value | Gene Name |
|---|---|---|---|---|
| CE | rs13077495 | 0.006 | 1.90 × 10−5 | PPARG |
| CE | rs206936 | −0.0018 | 0.00016 | RPS10-NUDT3 |
| CE | rs17793951 | 0.0036 | 0.00064 | PPARG |
| CE | rs189428681 | 0.0066 | 0.0015 | PPARG |
| CE | rs7578465 | −0.0016 | 0.0019 | ALK |
| CE | rs191018871 | 0.0062 | 0.0021 | PPARG |
| CE | rs7920888 | −0.0015 | 0.0043 | intergenic |
| CE | rs13041126 | −0.0015 | 0.0052 | intergenic |
| CE | rs6782178 | 0.0023 | 0.0056 | PPARG |
| CE | rs6810295 | 0.0014 | 0.006 | OSBPL10 |
| FE | rs2237892 | −0.01 | 0.00067 | KCNQ1 |
| FE | rs1413020 | 0.012 | 0.0062 | intergenic |
| FE | rs2972165 | 0.029 | 0.0072 | PPARG |
| FE | rs2389438 | 0.017 | 0.011 | intergenic |
| FE | rs2938398 | 0.0091 | 0.013 | PPARG |
| FE | rs11122577 | −0.0077 | 0.014 | AGT |
| FE | rs11142387 | 0.0074 | 0.019 | intergenic |
| FE | rs7551318 | −0.027 | 0.02 | intergenic |
| FE | rs4243830 | −0.008 | 0.022 | PLEKHG5 |
| FE | rs4144743 | −0.0066 | 0.023 | intergenic |
| TE | rs2972164 | 0.00056 | 2.50 × 10−5 | PPARG |
| TE | rs11142387 | 0.00032 | 4.10 × 10−5 | intergenic |
| TE | rs13077495 | 0.0009 | 5.70 × 10−5 | PPARG |
| TE | rs206936 | −0.00029 | 0.0001 | RPS10-NUDT3 |
| TE | rs67216730 | 0.00062 | 0.00044 | PPARG |
| TE | rs2920502 | 0.00026 | 0.00059 | PPARG |
| TE | rs7578465 | −0.00025 | 0.0014 | ALK |
| TE | rs13041126 | −0.00022 | 0.0032 | intergenic |
| TE | rs12150665 | 0.00021 | 0.0047 | GGNBP2 |
| TE | rs4327120 | 0.00024 | 0.0048 | intergenic |
| EE | rs4432245 | −0.14 | 0.0065 | EIF2AK4 |
| EE | rs10929925 | −0.14 | 0.0065 | intergenic |
| EE | rs4762 | −0.21 | 0.013 | AGT |
| EE | rs7164727 | 0.15 | 0.013 | intergenic |
| EE | rs2770102 | −0.18 | 0.014 | LINC00340 |
| EE | rs11583200 | 0.19 | 0.015 | ELAVL4 |
| EE | rs2228213 | −0.13 | 0.021 | HIVEP1 |
| EE | rs1205 | 0.12 | 0.021 | CRP |
| EE | rs2845885 | 0.12 | 0.028 | MACROD1 |
| EE | rs3093059 | 0.16 | 0.03 | CRP |