Table 5.
Association of child nutrient intake rank at three years (1-timepoint) with global DNA methylation.
| Model 1 | N | Nutrient | Outcome 2 | Association (95% CI) | P-Value | R-Square |
|---|---|---|---|---|---|---|
| 1 | 57 | Methionine | DNA methylation % | −0.017 (−0.18 to 0.14) | 0.83 | 0.08 |
| 2 | 57 | Vitamin B2 (Riboflavin) |
DNA methylation % | −0.037 (−0.2 to 0.13) | 0.66 | 0.08 |
| 3 | 57 | Vitamin B6 (Pyridoxine) |
DNA methylation % | −0.086 (−0.24 to 0.07) | 0.26 | 0.10 |
| 4 | 57 | Vitamin B12 (Cobalamin) |
DNA methylation % | 0.100 (−0.06 to 0.26) | 0.23 | 0.10 |
| 5 | 57 | Choline | DNA methylation % | 0.037 (−0.12 to 0.19) | 0.64 | 0.08 |
| 6 | 57 | Folate | DNA methylation % | −0.062 (−0.21 to 0.09) | 0.41 | 0.09 |
1 All models were adjusted for child gender, models 2, 3 and 4 were for vitamin B2, B6 and B12 supplement use during pregnancy and model 6 were adjusted for folic acid supplement use during pregnancy; 2 The natural logarithm transformation of global DNA methylation was used for the linear regression models to meet normality assumptions.