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. 2018 Mar 1;10(3):292. doi: 10.3390/nu10030292

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Maternal folic acid supplementation improved sensory-motor development in offspring. Dams were randomly assigned to a folate-normal diet group (ND), a folate-deficient diet group (DD), a folic acid-supplemented diet short-period group (FD-S), and a folic acid-supplemented diet long-period group (FD-L). Thirty pups (15 female and 15 male pups) were selected randomly from each diet group (4–5 offspring from each dam) for the cliff avoidance test at PD4-8 and the forelimb grip test at PD8-14. (A) Cliff avoidance test for male offspring (n = 15/group); (B) Cliff avoidance test for female offspring (n = 15/group); (C) Forelimb grip test for male offspring (n = 15/group); (D) Forelimb grip test for female offspring (n = 15/group). Data of cliff avoidance test are expressed as proportion, and data of forelimb grip test are expressed as mean ± SD. * Comparing with four groups at α = 0.05/(comparisons times).