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Down-regulation of survivin is attributed to the inactivation of TOPK. (A) Influences of GCM, ABT-737 and the combination on phosphorylation of TOPK and survivin analyzed by western blot in vitro; (B) Analysis of p-H3 and p-survivin in tumor samples by western blot; (C) Effects of TOPK knockdown on survivin expression; (D) Influences of TOPK knockdown on cell death induction by ABT-737. p < 0.05 (*), p < 0.005 (**).
