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. 2018 Mar 15;10(3):353. doi: 10.3390/nu10030353

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inhibition of de novo lipogenesis contributes to sensitization effect of GCM in vitro and in vivo. (A,B) Effects of GCM, ABT-373 and the combination on phosphorylation of AMPK and its substrate ACC measured by western blot in vitro (A) and in vivo (B); (C) Influences of lipogenesis inhibition by orlistat on apoptosis induced by ABT-737 in HepG2 cells; (D) Inhibitory effect of orlistat, ABT-737 and the combination on tumor growth; (E,F) Reduction of the final tumor weight by of orlistat or/and ABT-737; (G) Body weight kinetics of mice. p < 0.05 (*), p < 0.005 (**).

Inhibition of de novo lipogenesis contributes to sensitization effect of GCM in vitro and in vivo. (A,B) Effects of GCM, ABT-373 and the combination on phosphorylation of AMPK and its substrate ACC measured by western blot in vitro (A) and in vivo (B); (C) Influences of lipogenesis inhibition by orlistat on apoptosis induced by ABT-737 in HepG2 cells; (D) Inhibitory effect of orlistat, ABT-737 and the combination on tumor growth; (E,F) Reduction of the final tumor weight by of orlistat or/and ABT-737; (G) Body weight kinetics of mice. p < 0.05 (*), p < 0.005 (**).