Table 4.

EF1 for Individual Methods and Best Individual Performance^a

Target Class	Target	Individual Programs								Best
		AD4	DOCK6	FRED	HYBRID	PLANTS	rDock	Smina	Surflex
GPCR	ADRB1	5	25	7	19	19	13	6	13	25
GPCR	DRD3	4	1	10	10	3	1	2	3	10
ion channel	GRIA2	4	13	32	47	14	4	8	13	47
kinase	BRAF	4	9	18	29	0	12	14	11	29
kinase	CDK2	15	4	18	30	4	17	10	4	30
kinase	PLK1	6	2	9	10	1	10	0	0	10
kinase	SRC	6	3	5	7	1	3	4	6	7
miscellaneous	FABP4	9	0	30	32	0	0	30	7	32
receptor	ESR1	32	8	37	36	17	29	23	20	37
receptor	ESR2	21	9	40	40	12	22	20	12	40
other enzymes	ACE	14	12	18	20	24	3	3	9	24
other enzymes	GLCM	4	12	4	35	13	17	4	31	35
other enzymes	HDAC8	0	27	31	30	15	2	32	2	32
other enzymes	HIVINT	0	11	8	10	15	7	8	5	15
other enzymes	PDE5A	7	9	20	31	15	10	12	5	31
other enzymes	PTN1	12	15	21	19	21	26	21	15	26
protease	ADA17	0	0	8	17	6	10	14	10	17
protease	FA10	26	16	17	19	12	27	18	8	27
protease	HIVPR	2	9	6	10	15	5	6	13	15
protease	MMP13	12	6	18	30	15	3	4	11	30
protease	TRY1	7	16	17	20	17	14	3	39	39
	mean	9	10	18	24	11	11	11	11	27
	std. dev.	9	7	11	11	7	9	9	9	11

^aColors represent a 3-point gradient from worst (red) to best (green). “Best” indicates the best performance across docking programs.