Figure 4.

Basal and S4048-inhibited glucose absorption in the isolated perfused intestine and liver of control (closed bars) and RIPGLUT1×GLUT2^−/− (open bars) mice. Intestine and liver were perfused as described in the legend to Fig. 3. Glucose absorption is calculated by the area under the portal glucose concentration curve multiplied by the flow rate. Glucose (150 mg within 1 min) was applied as an intraluminal bolus in minute 6 and again in minute 41. From the 11th to the 45th minute of the experiment, S4048 was infused with the effective concentrations given in the figure into the mesenteric artery. Values are means ± SEM of 4–5 experiments each.