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. 2018 Mar 15;2(6):597–606. doi: 10.1182/bloodadvances.2017010975

Figure 3.

Figure 3.

Size and granularity of in vitro–grown megakaryocytes in the presence of inhibitors. (A) Representative data of FSC on day 12 of in vitro–grown, CD42bHigh megakaryocytes. Cells have a wide size distribution, but with most of them being small megakaryocytes. Horizontal lines in the graphs indicate size range of the megakaryocytes classified as “large” megakaryocytes with FSC >70% of FSC of the control sample. (B) Mean percentage ± 1 SEM of the day 12, in vitro–grown, CD42bHigh inhibitor-treated and control megakaryocytes. P values were determined using 1-way ANOVA in comparison with the control. (C) Representative data of SSC of day 12, in vitro–grown, CD42bHigh megakaryocytes. Cells have wide granularity distribution, with most of them being low-granular megakaryocytes. Horizontal lines in the graphs indicate granularity range of the megakaryocytes classified as high-granular megakaryocytes with SSC >70% of the SSC in the control sample. (D) Mean percentage ± 1 SEM of the day 12, in vitro–grown, CD42bHigh inhibitor-treated and control megakaryocytes that are high-granular (HG). In both panels B and D, N = ≥6 independent experiments. P values were determined using 1-way ANOVA in comparison with the control.