Table 1.
Patient | Dose level | Diagnosis | HCT regimen intensity | Time from HCT to relapse, d | Treatment before CD8+ TM cell infusion | Time from relapse to CD8+ TM cell infusion, d | Disease status at CD8+ TM cell infusion |
---|---|---|---|---|---|---|---|
1 | 1 | AML | NMA | 865 | Chemotherapy | 236 | CR2 |
2 | 1 | AML | NMA | 118 | None | 7 | Active disease |
3 | 1 | AML | MA | 2325 | Chemotherapy | 183 | CR3 |
4 | 2 | AML | MA | 167 | Chemotherapy | 134 | CR2 |
5 | 2 | CML | MA | 1531 | Chemotherapy | 799 | CR3 |
6 | 2 | CLL | NMA | 437 | Chemotherapy | 498 | Active disease |
7 | 3 | AML | NMA | 59 | Chemotherapy | 98 | Active disease |
8 | 3 | AML | RIC | 214 | Chemotherapy | 135 | Active disease |
9 | 3 | NHL | NMA | 93 | Chemotherapy | 1106 | Active disease |
10 | 3 | NHL | NMA | 704 | Chemotherapy | 337 | Active disease |
11 | 3 | AML | MA | 3214 | Chemotherapy | 91 | CR2 |
12 | 3 | AML | MA | 1361 | Chemotherapy | 418 | CR3 |
13 | 3 | NHL | NMA | 508 | Chemotherapy | 855 | Active disease |
14 | 3 | MM | NMA | 878 | Chemotherapy | 3005 | Active disease |
15 | 3 | ALL | RIC | 303 | None | 125 | Active disease |
ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; CLL, chronic lymphocytic leukemia; CML, chronic myeloid leukemia; CR2, second complete remission; CR3, third complete remission; MA, myeloablative; MM, multiple myeloma; NHL, non-Hodgkin lymphoma; NMA, non-myeloablative; RIC, reduced-intensity conditioning.