. 2017 Dec 19;20(2):227–236. doi: 10.1177/1099800417747411

Table 3.

Levels of Targeted Metabolites Before and After Chemotherapy (Mean ± SD).

Metabolite	Before Chemo (N = 19)	After Chemo (N = 19)	p	q ^a
Kynurenine (ng/dl)	209 ± 62	272 ± 70	.026^b	.052^b
Serotonin (ng/dl)	164 ± 121	95 ± 66	.104	.104
Tryptophan (ng/dl)	8,549 ± 2,127	6,849 ± 2,135	.066	.088
K/T ratio	2.6 ± 0.9	4.5 ± 2.0	.009^b	.036^b

Note. K/T ratio = ratio of kynurenine to tryptophan.

^aAn estimate of the false discovery rate, which is given by the q value, was calculated to take into account the multiple comparisons that normally occur in metabolomic-based studies. A low q value (q < .10) is an indication of high confidence in a result. ^bStatistically significant change from before to after chemotherapy.